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GCRC at University of Washington Medical Center
(206) 598-4700
gcrc@u.washington.edu

Pediatric CRC at Children's Hospital and Regional Medical Center
(206) 987-3897
PediatricCRC@seattlechildrens.org

Publications, December 2002-March 2004

UW GCRC
The following are articles that have been published or accepted for publication based on assistance given and/or research performed at the University of Washington GCRC for the reporting period 12/1/2002 - 3/31/2004

Aprikyan, A.A.G., Kutyavin, T., Stein, S., Aprikian, P., Rodger, E., Liles, W.C., Boxer, L.A., Dale, D.C. Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia. Exper Hematol. 2003. 31:372-381.

Brooks-Worrell, B.M., Greenbaum, C.J., Palmer, J.P., Pihoker, C. Autoimmunity to islet proteins in children diagnosed with new-onset diabetes. J Clin Endocrinol Metab. 2004. 89:2222-2227.

Brown, A.J.L., Frost, S.D.W., Good B., Daar, E.S., Simon, V., Markowitz, M., Collier, A.C., Connick, E., Conway, B., Margolick, J.B., Routy, J-P., Corbeil, J., Hellmann, N.S., Richman, D.D., Little, S.J. Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacvity of human immunodeficiency virus type 1 strains in primary infection. J Virology. 2004. 78(5):2242-2246.

Callahan, H.S., Cummings, D.E., Pepe, M.S., Breen, P.A., Matthys, C.C., Weigle, D.S. Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metab. 2004. 89(3):1319-1324.

Carr, M.C., Ayyobi, A.F., Murdoch, S.J., Deeb, S.S., Brunzell, J.D. Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women . Arterio Thromb Vasc Biol. 2002. 22(4):667-673.

Carr, M.C., Brunzell, J.D., Deeb, S.S. Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: Role of central obesity and LIPC polymorphisms. J Lipid Res. 2004. 45:466-473.

Cheung, M.C., Sibley, S.D., Palmer, J.P., Oram, J.F., Brunzell, J.D. Lipoprotein lipase and hepatic lipase: Their relationship with HDL subspecies (Lp(A-1) and Lp(A-I,A-II). J Lipid Res. 2003. 44:1552-1558.

Cnop, M., Havel, P.J., Utzschneider, K.M., Carr, D.B., Sinha, M.K., Boyko, E.J., Retzlaff, B.M., Knopp, R.H., Brunzell, J.D., Kahn, S.E. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia. 2003. 46:459-469.

Cnop, M., Landchild, M.J., Vidal, J., Havel, P.J., Knowles, N.G., Carr, D.R., Wang, F., Hull, R.L., Boyko, E.J., Retzlaff, B.M., Walden, C.E., Knopp, R.H., Kahn, S.E. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: Distinct metabolic effects of two fat compartments. Diabetes. 2002. 51:1005-1015.

Dale, D.C., Cottle, T.E., Fier, C.J., Bolyard, A.A., Bonilla, M.A., Boxer, L.A., Cham, B., Freedman, M.H., Kannourakis, G., Kinsey, S.E., Davis, R., Scarlata, D., Schwinzer, B., Zeidler, C., Welte, K. Severe chronic neutropenia: Treatment and follow-up of patients in the severe chronic neutropenia international registry. Am J Hematol. 2003. 72:82-93.

Dale, O., Hoffer, C., Sheffels, P., Kharasch, E.D. Disposition of nasal, intravenous, and oral methadone in healthy volunteers. Clin Pharmacol Ther. 2002. 72:536-545.

Deeb, S.S., Zambon, A., Carr, M.C., Ayyobi, A.F., Brunzell, J.D. Hepatic lipase and dyslipidemia: Interactions among genetic variants, obesity, gender, and diet. J Lipid Res. 2003. 44:1279-1286.

Diabetes Control and Complications Trial/Epedemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 Diabetes mellitus on development and progression of diabetic nephropathy: The epidemiology of diabetes interventions and complications (EDIC) study. JAMA. 2003. 290(16):2159-2167.

Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Intensive diabetes therapy and carotid intima-Media thickness in type 1 Diabetes mellitus . N Engl J Med. 2003. 348:2294-2303.

Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes. Diabetes Care. 2003. 26(5):1439-1448.

Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort. Diabetes Care. 2003. 26(3):810-818.

DiCenzo, R., Forrest, A., Fischl, M.A., Collier, A., Feinberg, J., Ribaudo, H., DiFrancecso, R., Morse, G.D., AIDS Clinical Trials Group 388/733/5060 Study Team. Pharmacokinetics of indinavir and nelfinavir in treatment-naive, human immunodeficiency virus-infected subjects. Antimicrobial Agents Chemotherapy. 2004. 48(3):918-923.

Diem, P., Laederach-Hofmann, K., Navarro, X., Mueller, B., Kennedy, W.R., Robertson, R.P. Diagnosis of diabetic autonomic neuropathy: A multivariate approach. Eur J Clin Invest. 2003. 33(8):693-697.

Disis, M.L., Goodell, V., Schiffman, K., Knutson, K.L. Humoral epitope spreading following immunication with a HER-2/neu peptide based vaccine in cancer patients. In Press. 2004. Accepted 2/1/2004.

Disis, M.L., Schiffman, K., Guthrie, K., Salazar, L.G., Knutson, K.L., Goodell, V., dela Rosa, C., Cheever, M.A. Effect of dose on immune response in patients vaccinated with a HER-2/neu intracellular domain protein based vaccine. In Press. 2004. Accepted 1/1/2004.

Emery, M.G., Fisher, J.M., Chien, J.Y., Kharasch, E.D., Dellinger, E.P., Kowdley, K.V., Thummel, K.E. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology. 2003. 38:428-435.

Ensinck, J.W., Laschansky, E.C., Vogel, R.E., D'Alessio, D.A. Effect of ingested nutrients on the release of thrittene into the human circulation. J Clin Endocrinol Metab. 2003. 88:4798-4804.

Fischl, M.A., Ribaudo, H.J., Collier, A.C., Giuliano, E.A., Dehlinger, M., Eron, J.J., Jr., Saag, M.S., Hammer, S.M., Vella, S., Morse, G.D., Feinberg, J.E., Denter, L.M., Eshleman, S.H., Adult Aids Clinical Trials Group 388 study team. A randomized trial of 2 different 4-drug antiretroviral regimens versus a 3-drug regimen, in advanced human immunodificiency virus disease. J Infect Dis. 2003. 188(5):625-634.

Grant, G.A., Britz, G.W., Goodkin, R., Jarvik, J.G., Maravilla, K., Kliot, M. The utility of magnetic resonance imaging in evaluating peripheral nerve disorders. Muscle Nerve. 2002. 25(3):314-331.

Greenbaum, C., Seidel, K., Pihoker, C. The case for intravenous arginine stimulation in lieu of mixed-meal tolerance tests as outcome measure for intervention studies in recent-onset type 1 diabetes. Diabetes Care. 2004. 27(5):1202-1204.

Greenbaum, C.J., Harrison, L.C., Immunology of Diabetes Society. Perspectives in Diabetes: Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes. Diabetes. 2003. 52:1059-1065.

Hayashi, T., Boyko, E.J., Leonetti, D.L., McNeely, M.J., Newell-Morris, L., Kahn, S.E., Fujimoto, W.Y. Visceral adiposity and the prevalence of hypertension in Japanese Americans. Circulation. 2003. 108:1718-1723.

Hebert, M.F., Park, J.M., Chen, Y-L., Akhtar, S., Larson, A.M. Effects of St. John's wort (Hypericum perforatum) on tacrolimus pharmacokinetics in healthy volunteers. J Clin Pharmacol. 2004. 44:89-94.

Herbst, K.L., Tannock, L.R., Deeb, S.S., Purnell, J.Q., Brunzell, J.D., Chait, A. Kobberling type of familial partial lipodystrophy: An underrecognized syndrome. Diabetes Care. 2003. 26:1819-1824.

Ho, W.Y., Blattman, J.N., Dossett, M.L., Yee, C., Greenberg, P.D. Adoptive immunotherapy: Engineering T cell responses as biologic weapons for tumor mass destruction. Cancer Cell. 2003. 3:431-437.

Ibrahim, A.E., Feldman, J., Karim, A., Kharasch, E.D. Simultaneous assessment of drug interations with low- and high-extraction opioids: Application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. Anesthesiology. 2003. 98(4):853-861.

Irwin, M.L., Yasui, Y., Ulrich, C.M., Bowen, D., Rudolph, R.E., Schwartz, R.S., Yukawa, M., Aiello, E., Potter, J.D., McTiernan, A. Effect of exercise on total and intra-abdominal body fat in postmenopausal women: A randomized controlled trial. JAMA. 2003. 289(3):323-330.

Jarvik, J.G., Yuen, E., Haynor, D.R., Bradley, C.M., Fulton-Kehoe, D., Smith-Weller, T., Wu, R., Kliot, M., Kraft G., Wang, L., Erlich, V., Heagerty, P.J., Franklin, G.M. MR nerve imaging in a prospective cohort of patients with suspected carpal tunnel syndrome. Neurology. 2002. 58(11):1583-1584.

Jenkins, A.J., Lyons, T.J., Zheng, D., Otvos, J.D., Lackland, D.T., McGee, D., Garvey, W.T., Klein, R.L., Diabetes Control and Complications Trial/Epedemiology of Diabetes Interventions and Complications Research Group. Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: Associations with gender and glycemia. Diabetes Care. 2003. 26:810-818.

Jenkins, A.J., Lyons, T.J., Zheng, D., Otvos, J.D., Lackland, D.T., McGee, D., Garvey W.T., Klein, R.L., Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Lipoproteins in the DCCT/EDIC cohort: Associations with diabetic nephropathy. Kidney International. 2003. 64:817-828.

Kahn, S.E. Review: The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia. 2003. 46:3-19.

Kharasch, E.D., Hoffer, C., Whittington, D., Sheffels, P. Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. Clin Pharmacol Ther. 2003. 74:543-554.

Klein, R.L., Hunter, S.J., Jenkins, A.J., Zheng, D., Semler, A.J., Clore, J., Garvey, W.T., Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: Studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort. Diabetes Care. 2003. 26:1439-1448.

Knopp, R.H., Retzlaff, B., Aikawa, K., Kahn, S.E. Management of patients with diabetic hyperlipidemia. Am J Cardiol. 2003. 91:24E-28E.

Knopp, R.H., Retzlaff, B., Fish, B., Walden, C., Wallick, S., Anderson, M., Aikawa, K., Kahn, S.E. Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding. Arterio Thromb Vasc Biol. 2003. 23(8):1437-1443.

Knowles, N.G., Landchild, M.A., Fujimoto, W.Y., Kahn, S.E. Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes. Diabetes Care. 2002. 25:292-297.

Krischer, J.P., Cuthbertson, D.D., Yu, L., Orban, T., Maclaren, N., Jackson, R., Winter, W.E., Schatz, D.A., Palmer, J.P., Eisenbarth, G.S., Diabetes Prevention Trial-Type 1 Study Group. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab. 2003. 88:103-108.

Liles, W.C., Broxmeyer, H.E., Rodger, E., Wood, B., Hubel, K., Cooper, S., Hangoc, G., Bridger, G.J., Henson, G.W., Calandra, G., Dale, D.C. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood. 2003. 102(8):2728-2730.

Lyons, T.J., Jenkins, A.J., Zheng, D., Lackland, D.T., McGee, D., Garvey, W.T., Klein, R.L., Diabetes Control and Complications Trial/Epedemiology of Diabetes Interventions and Complications Research Group. Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort. Invest Ophthalmol Vis Sci. 2004. 45:910-918.

Mackey, M.D., Aprikyan, A.A.G., Dale, D.C. The rate of apoptosis in post mitotic neutrophil precursors of normal and neutropenic humans. Cell Prolif. 2003. 36:27-34.

McIlroy, D.R., Kharasch, E.D. Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia. Anesth Analg. 2003. 96:1572-1577.

McNeel, D.G., Knutson, K.L., Schiffman, K., Davis, D.R., Caron, D., Disis, M.L. Pilot study of an HLA-A2 peptide vaccine using flt3 ligand as a systemic vaccine adjuvant. J Clin Immunol. 2003. 23:62-72.

Merriam, G.R., Schwartz, R.S., Vitiello, M.V. Growth hormone-releasing hormone and growth hormone secretagogues in normal aging. Endocrine. 2003. 22(1):1-8.

Moe, K.E. Hot flashes and sleep in women. Sleep Med Rev. 2004. Accepted 2/12/2004.

Moss, R.B., Rodman, D., Spencer, L.T., Aitken, M.L., Zeitlin, P.L., Waltz, D., Milla, C., Brody, A.S., Clancy, J.P., Ramsey, B., Hamblett, N., Heald, A.E. Repeated Adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: A multicenter, double-blind, placebo-controlled trial. Chest. 2004. 125:509-521.

Murdoch, S.J., Carr, M.C., Kennedy, H., Brunzell, J.D., Albers, J.J. Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution. J Lipid Res. 2002. 43(8):1256-1263.

Murdoch, S.J., Kahn, S.E., Albers, J.J., Brunzell, J.D., Purnell, J.Q. PLTP activity decreases with weight loss: Changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity. J Lipid Res. 2003. 44:1705-1712.

Naik, R.G., Lernmark, A., Palmer, J.P. Pathophysiology and genetics of type (insulin-dependent) diabetes. In: Diabetes Mellitus: Theory and Practice, 6th Edition (Porte Jr. D., Sherwin, R., Baron, A.D., eds); McGraw-Hill, New York. . 2004. :301-329.

Nieves, D.J., Cnop, M., Retzlaff, B., Walden, C.E., Brunzell, J.D., Knopp, R.H., Kahn, S.E. The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes. 2003. 52:172-179.

O'Brien, K.D., Zhao, X-Q., Shavelle, D.M., Caulfield, M.T., Letterer, R.A., Kapadia, S.R., Probstfield, J.L., Otto, C.M. Hemodynamic effects of the angiotensin converting enzyme inhibitor, ramipril, in patients with mild-to-moderate aortic stenosis and preserved left ventricular function. In press. 2004. Accepted 2/1/2004.

Ordonez, C.L., Henig, N.R., Mayer-Hamblett, N., Accurso, F.J., Burns, J.L., Chmiel, J.F., Daines, C.L., Gibosn, R.L., McNamara, S., Retsch-Bogart, G.Z., Zeitlin, P.L., Aitken, M.L. Inflammatory and microbiologic markers in inducd sputum after intravenous antibiotics in cystic fibrosis. Am J Respir Crit Care Med. 2003. 168(12):1471-1475.

Palmer, J.P., Fleming, G.A., Greenbaum, C.J., Herold, K.C., Jansa, L.D., Kolb, H., Lachin, J.M., Polonsky, K.S., Skyler, J.S., Steffes, M.W. C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function - Report of an ADA workshop, 21-22 October 2001. Diabetes. 2004. 53:250-264.

Park, J.M., Lin, Y.S., Calamia, J.C., Thummel, K.E., Slattery, J.T., Kalhorn, T.F., Carithers, R.L., Levy, A.E., Marsh, C.L., Hebert, M.F. Transiently altered acetaminophen metabolism after liver transplantation. Clin Pharmacol Ther. 2003. 73:545-553.

Paty, B.W., Ryan, E.A., Shapiro, A.M.J., Lakey, J.R.T., Robertson, R.P. Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes. 2002. 51:3428-3434.

Pierce, C.H., Chen, Y.L., Dills, R.L., Morgan, M.S., Kalman, D.A. Toluene metabolites as biological indicators of exposure. Tox Lett. 2002. 129(1-2):65-76.

Pierce, C.H., Chen, Y.L., Hurtle, W., Morgan, M.S. Exponential modeling, washout curve reconstruction, and estimation of half-life of toluene and its metabolites. J Toxicol Environ Health. 2004. In press:.

Prigeon, R.L., Quddusi, S., Paty, B., D'Alessio, D.A. Suppression of glucose production by GLP-1 independent of islet hormones: A novel extrapancreatic effect. Am J Physiol Endocrinol Metab. 2003. 285:E701-E707.

Purnell, J.Q., Dev, R.K., Steffes, M.W., Cleary, P.A., Palmer, J.P., Hirsch, I.B., Hokanson, J.E., Brunzell, J.D. Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the diabetes control and complications trial. Diabetes. 2003. 52(10):2623-2629.

Purnell, J.Q., Weigle, D.S., Breen, P., Cummings, D.E. Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans. J Clin Endocrinol Metab. 2003. 88(12):5747-5752.

Quddusi, S., Vahl, T.P., Hanson, K., Prigeon, R.L., D-Alessioi, D.A. Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans. Diabetes Care. 2003. 26:791-798.

Robertson, R.P. Consequences of beta-cell function and reserve after long-term pancreas transplantation. Diabetes. 2004. 53:633-644.

Robertson, R.P. Editorial: Intrahepatically transplanted islets: Strangers in a strange land. J Clin Endocrin Mebab. 2002. 87(12):5416-5417.

Robertson, R.P. Review: Islet Transplantation as a treatment for diabetes - A work in progress. N Engl J Med. 2004. 350(7):694-705.

Robertson, R.P., Harmon, J., Tanaka, Y., Tran, P.O., Poitout, V. Glucose toxicity of the beta-cell: Cellular and molecular mechanisms. Diabetes Mellitus; LeRoith, Olefsky, Taylor (eds); Lippincott Williams Wilkins. 2002. 2nd Edition:129-139.

Robertson, R.P., Harmon, J., Tran, P.O., Tanaka, Y., Takahashi, H. Perspectives in Diabetes: Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes. 2003. 52:581-587.

Robertson, R.P., Harmon, J., Tran, P.O.T., Poitout, V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes. 2004. 53:S119-S124.

Robertson, R.P., Kendall, D.M. Islet transplantation 2003: Questions about its future. Curr Opin Endocrinol Diabetes. 2003. 10:128-132.

Robertson, R.P., Lanz, K.J., Sutherland, D.E.R., Seaquist, E.R. Relationship between diabetes and obesity 9 to 18 years after hemipancreatectomy and transplantation in donors and recipients. Transplantation. 2002. 73(5):736-741.

Robertson, R.P., Sutherland, D.E.R., Seaquist, E.R., Lanz, K.J. Glucagon, catecholamine, and symptom responses to hypoglycemia in living donors of pancreas segments. Diabetes. 2003. 52:1689-1694.

Salazar, L.G., Files, J., Southwood, S., Ishioka, G., Knutson, K.L., Gooley, T.A., Schiffman, K., Disis, M.L. Immunization of cancer patients with HER-2/neu-derived peptides demonstrating high-affinity binding to multiple class II alleles. Clin Cancer Res. 2003. 9:5559-5565.

Schacker, T., Zeh, J., Hu, H., Shaughnessy, M., Corey, L. Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression. J Infect Dis. 2002. 186:1718-1725.

Sibley, S.D., Palmer, J.P., Hirsch, I.B., Brunzell, J.D. Visceral obesity, hepatic lipase activity, and dyslipidemia in type 1 diabetes. J Clin Endocrinol Metab. 2003. 88(7):3379-3384.

Tworoger, S.S., Yasui, Y., Vitiello, M.V., Schwartz, R.S., Ulrich, C.M., Aiello, E.J., Irwin, M.L., Bowen, D., Potter, J.D., McTiernan, A. Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women. Sleep. 2003. 26(7):830-836.

Vitiello, M.V., Larsen, L.H., Moe, K.E. Age-related sleep change: Gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women. J Psychosomatic Res. 2004. In press:.

Vitiello, M.V., Moe, K.E., Larsen, L.H., Merriam, G.R., Schwartz, R.S. Long-term growth hormone releasing hormone administration does not improve the sleep quality of healthy older men and women. Sleep. 2003. 26:A154.

Weigle, D.S., Cummings, D.E., Newby, P.D., Breen, P.A., Frayo, R.S., Matthys, C.C., Callahan, H.S., Purnell, J.Q. Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet. J Clin Endocrinol Metab. 2003. 88(4):1577-1586.

Wilkin, T., Ludvigsson, J., Greenbaum, C., Palmer, J., Becker, D., Bruining, J. Future intervention trials in type 1 diabetes. Diabetes Care. 2004. 27(4):996-997.

Yee, C. Adoptive T cell therapy - immune monitoring and MHC multimers. Clin Immunol. 2003. 106:5-9.

Yee, C., Greenberg, P.D. Modulating T-cell immunity to tumors: New strategies for monitoring T-cell responses. Nat Rev Cancer. 2002. 2:409-419.

Yee, C., Thompson, J.A., Byrd, D., Riddell, S.R., Roche, P., Celis, E., Greenberg, P.D. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells. Immunology. 2002. 99(25):16168-16173.

Zambon, A., Deeb, S.S., Pauletto, P., Crepaldi, G., Brunzell, J.D. Hepatic lipase: A marker for cardiovascular disease risk and response to therapy. Curr Opin Lipidol. 2003. 14:179-189.

Zhao, X-Q., Morse, J.S., Dowdy, A.A., Heise, N., DeAngelis, D., Frohlich, J., Chait, A., Albers, J.J., Brown, B.G. Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis treatment study). Am J Cardiol. 2004. 93(3):307-312.

Children's Hospital and Regional Medical Center Pediatric CRC
The following are articles, published, in-print, or accepted for publication, based on assistance given and/or research performed at the Children's Hospital and Regional Medical Center Pediatric CRC for the reporting period 12/1/2002 - 3/31/2004.

Brooks-Worrell BM, Greenbaum CJ, Palmer JP, Pihoker C. Autoimmunity to Islet Proteins in Children Diagnosed with New Onset Diabetes. The Journal of Clinical Endocrinology and Metabolism. 2004. in press:.

Buchacz K, Rogol AD, Lindsey JC, Wilson CM, Hughes MD, Seage GR 3rd, Oleske JM, Rogers AS; Pediatric AIDS Clinical Trials Group 219 Study Team. Delayed onset of pubertal development in children and adolescents with perinatally acquired HIV infection. J Acquir Immune Defic Syndr. 2003. 33:56-65.

Endriga MC, Jordan JR, Speltz ML. Emotion self-regulation in preschool-aged children with and without orofacial clefts. J Dev Behav Pediatr. 2003. 24(5):336-44.

Frenkel LM, Wang Y, Learn GH, Melvin AJ, Ellis GM, McKernan JL, De Vange SM,Mohan KM, Holte S, Sylva GL, Naugler WE, Mahalanabis M, Beck IA, Lewis PA,Heath LM, Tobin NH, Pawluk D, Mullins JI. Multiple Viral Genetic Analyses Detect Low-level Human Immunodeficiency Virus type-1 Replication During Effective HAART. J Virol. 2003. 77:5721-30.

Geller DE, Rosenfeld M, Waltz DA, Wilmott RW, the AeroDose TOBI Study Group. Efficiency of Pulmonary Administration of Tobramycin Solution for Inhalation in Cystic Fibrosis Using an Improved Drug Delivery System. CHEST. 2003. 123:28-36.

Gibson FL, Emerson J, McNamara S, Burns JL, Rosenfeld M, Hamblett N, Acton J, Borowitz D, Hiatt P, Konstan MW, Moss R, Retsch-Bogart G, Wagener J, Waltz D, Zeitlin PL, Ramsey B. Duration of the Anti-pseudomonal Treatment Effect of Inhaled Tobramycin in Young Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2003. 167:841-9.

Gibson RL, Emerson J, McNamara S, Burns JL, Rosenfeld M, Yunker A, Hamblett N, Accurso F, Dovey M, Hiatt P, Konstan MW, Moss R, Retsch-Bogart G, Wagener J, Waltz D, Wilmott R, Zeitlin PL, Ramsey B, Cystic Fibrosis Therapeutics Development Network Study Group. Significant Microbiological Effect of Inhaled Tobramycin in Young Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2003. 167:841-849.

Greenbaum C, Seidel K, Pihoker C. The Case for IV Arginine Stimulation In Lieu of MMTT as Outcome Measure for Intervention Studies in Recent Onset Type 1 Diabetes. Diabetes Care. 2004. Accepted 1/9/2004.

Gunther DF, Eugster E, Zagar AJ, Bryant CG, Davenport ML, Quigley CA. Ascertainment bias in Turner syndrome: New Insights from girls diagnosed incidentally in prenatal life. Pediatrics. 2004. Accepted 3/1/2004.

Juul SE. Enterally Dosed Recombinant Human Erythropoietin Does Not Stimulate Erythropoiesis In Neonates. The Journal of Pediatrics. 2003. 143:321-326.

Konduri GG, Solimano A, Sokol GM, Singer J, Ehrenkranz RA, Singhal N, Wright LL, Van Meurs K, Stork E, Kripalani H, Peliowski A, Neonatal Inhaled Nitric Oxide Study Group. A Randomized Trial of Early Versus Standard Inhaled Nitric Oxide Therapy in Term and Near Term Newborn Infants with Hypoxic Respiratory Failure. Pediatrics. 2004. Accepted 12/1/2003.

Lovell DJ, Giannini EH, Reiff A, Jones OY, Schneider R, Olson JC, Stein LD, Gedalia A, Ilowite NT, Wallace CA, Lange M, Finck BK, Burge DJ; Pediatric Rheumatology Collaborative Study Group. Long-term efficacy and safety of etanercept in children with polyarticular-course juvenile rheumatoid arthritis: interim results from an ongoing multicenter, open-label, extended-treatment trial. Arthritis Rheum. 2003. 48(1):218-26.

Nichols KE, Heath JA, Friedman D, Biegel JA, Ganguly A, Mauch P, Diller L. TP53, BRCA1, and BRCA2 tumor suppressor genes are not commonly mutated in survivors of Hodgkin's disease with second primary neoplasms. J Clin Oncol. 2003. 21(24):4505-9.

Phimmasone S, Kharasch ED. A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. Clin Pharmacol Ther. 2001. 70(6):505-17.

Rosenfeld M, Ramsey BW, Gibson RL. Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and management. Curr Opin Pulm Med. 2003. 9:492-497.

Smith JM, Jones F, Ciol MA, Jelacic S, Boster DR, Watkins SL, Williams GD, Tarr PI, Henderson WR Jr. Platelet-activating factor and Escherichia coliO157:H7 infections. Pediatr Nephrol. 2002. 17(12):1047-52.

Soh CH, Oleske JM, Brady MT, Spector SA, Borkowsky W, Burchett SK, Foca MD, Handelsman E, Jimenez E, Dankner WM, Hughes MD; Pediatric AIDS Clinical Trials Group. Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents. Lancet. 2003. 362:2045-51.

Yasui Y, Liu Y, Neglia JP, Friedman DL, Bhatia S, Meadows AT, Diller LR, Mertens AC, Whitton J, Robison LL. A methodological issue in the analysis of second-primary cancer incidence in long-term survivors of childhood cancers. Am J Epidemiol. 2003. 158(11):1108-13.

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