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About the GCRC
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Current Research
Each quarter, the program directors feature a high-impact publication and an active study
using GCRC resources. We also list active protocols and
publications over the past year.
Hayashi T, Boyko EJ, Leonetti DL, McNeely MJ, Newell-Morris L, Kahn SE, Fujimoto WY. Visceral
adiposity is an independent predictor of incident hypertension in Japanese Americans. Ann
Intern Med 2004 Jun 15; 140(12):992-1000.
This paper is a well described and well controlled prospective
study of the association of visceral adiposity and the risk of hypertension in Japanese
Americans. Few studies of this length of follow-up or scientific rigor in collecting pertinent
correlative data have been performed. The study, conducted at the University of Washington GCRC
Adult Unit, used computed tomography (CT) scans to measure multiple body fat areas of 300 middle
aged Japanese Americans who did not have hypertension. 92 subjects developed hypertension over
the next 10-11 years. Greater visceral adiposity was an independent risk factor for the
development of high blood pressure. Of note, other areas of fat were not associated with
hypertension. The use of CT measured intra-abdominal fat allowed very precise analysis and
has set the "bar" for such studies. The etiology or mechanism behind the association
has not been defined but is an area of ongoing study.
 link to the full article on ProQuest
Publications in the last two years:
Other high-impact publications featured in the current slideshow:
- Montgomery RB, Makary E, Schiffman K, Goodell V, Disis ML. Endogenous anti-HER2 antibodies block HER2 phosphorylation and signaling through extracellular signal-regulated kinase. Cancer Res 2005 Jan 15;65(2):650-6.
- Disis ML, Schiffman K, Guthrie K, Salazar LG, Knutson KL, Goodell V, dela Rosa C, Cheever MA. Effect of dose on immune response in patients vaccinated with an her-2/neu intracellular domain protein--based vaccine. J Clin Oncol 2004 May 15;22(10):1916-25.
- Roder ME and Kahn SE. Suppression of Beta-cell secretion by somatostatin does not fully reverse the disproportionate proinsulinemia of type 2 diabetes. Diabetes 2004 Dec;53 Suppl 3:S22-5.
Wondering what is considered a "high-impact" publication? Each year, over 6000
international science journals are ranked in the ISI Journal Citation Reports. Learn more
about the ISI Journal Citation Reports
here and look
up journal rankings here.
Active Protocols:
A Phase I study to evaluate the safety of cellular immuno-therapy using genetically-modified
autologous CD20-specific CD8+ T cell clones for patients with relapsed CD20+ indolent lymphomas.
PI: Oliver Press, MD, PhD.
This phase I study will test the safety of using gene therapy to treat patients with relapsed
or refractory follicular non-Hodgkin's lymphoma. To improve the body's immune system to fight
lymphoma after CVP chemotherapy, this clinical trial uses immune cells, called cytotoxic
T-lymphocytes (CTL) or "killer" T-cells, that are genetically modified to attack lymphoma
cells. This study will also examine how a patient's lymphoma responds to the genetically
modified CTL immune cells, how long these CTL remain in the body, where these cells travel
in the body, and if the body develops an immune response to these CTL cells.
This study uses the
cGMP Gene and
Cell Therapy Core Laboratory.
The Impact of omega-3 polyunsaturated fatty acids on the metabolism of adiposity hormones.
PI: D. Scott Weigle, M.D..
The main focus of this study is to measure the effects of dietary fat on the levels of fats
(such as cholesterol) and hormones in your blood. We are particularly interested in certain
hormones, such as insulin, that regulate how your body deals with sugar and fat. Some of
these hormones are also involved in the regulation of your body weight and body composition.
more
This study uses the
Nutrition
Research Core.
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