Medicine Residency Program Research Rotation — Mentors

Abkowitz, Janis L., M.D. Professor, Medicine, Division of Hematology

(206) 685-7877 or 543-3360
janabk@u.washington.edu

There are two active project areas: 1. hematopoietic stem cells (HSC) and 2. heme/iron trafficking. The studies of HSC investigate the role of the hematopoietic microenvironment in defining a niche or geographic site where HSC can survive. We also study how HSC migrate within the marrow compartment during normal blood cell production and in the myeloproliferative disorders. These studies span from experiments in mice with specific genetic defects to the stochastic modeling of HSC fate decisions (a collaboration with Peter Guttorp, Chair of Statistics, UW). The studies of heme/iron trafficking concern FLVCR, a novel membrane transporter we have cloned (Cell 118:7575, 2004) which is well-conserved evolutionarily and exports cytoplasmic heme. Our current studies address the role of heme export in insuring effective erythroid differentiation, the importance of heme export after monocyte erythrophagocytosis, and the role of FLVCR in the export of heme from liver to bile. Potential projects could be basic (requiring molecular biology skills) or applied (using cell culture or conditional FLVCR null mice), depending on the background and interest of the resident. We see this as an opportunity for someone interested in combining bench research with clinical medicine to understand how physiologic questions (motivated by patient observations) translate into basic research studies.

Abrass, Christine K., M.D. Professor of Medicine, University of Washington School of Medicine

Nephrology

(206) 277-3242
cabrass@u.washington.edu

The glomerulus is a specialized vascular structure that allows glomerular filtration to occur. Specific isoforms of laminin are expressed within the glomerulus that influence the function of the three glomerular cell types that create the glomerulus. Disorders that alter the amount and isoform of laminin expressed in the glomerulus alter the function of these cells. Glucose, insulin, insulin-like growth factor 1 and its binding protein 5 are altered in glomerular diseases such as diabete mellitus. These factors alter glomerular function in part by changing the isoform of laminin that is expressed and consequently the cell that is attached to it. We are investigating the mechanisms whereby these growth factors alter the laminin isoforms and the cellular consequences.

Ahmad, Suhail ,M.D.

Acting Section Chief, Nephrology, Medical Director, Dialysis/ Apheresis, UW, Medical Director, Scribner Kidney Center

Nephrology

sahmad@u.washington.edu

1. Hypertension: Clinical Trials of New Agents e.g. planning stage of evaluating a new renin blocker in essential hypertension; long term studies in hypertension; secondary hypertension - specifically aldo and parathyroid. 2. Clinical Dialysis: all aspects of hemodialysis and peritoneal dialysis.

Albers, John J., M.D.

Research Professor of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratory; Adjunct Research Professor, Pathology

Metabolism

(206) 685-3330 or 685-3332
jja@u.washington.edu

The longterm objective is to elucidate the molecular and genetic abnormalities of human liporotein metabolism that predispose to premature coronary heart disease or contribute to neurological disorders.His work currently focuses on defining the the functional and pathophysiological role of the lipid transfer proteins, with a specific interest on plasma phospholipid transfer protein(PLTP). PLTP is ubiquitously present in tissues and plasma, where it plays diverse roles in lipid and lipoprotein metabolism, including transfer of phospholipid and cholesterol among lipoproteins and between lipoproteins and cells. Current data indicate that most PLTP in human plasma associates with distinct HDL particles and lacks the ability to transfer lipids in vitro. Therefore we plan to establish the structural basis and metabolic and pathologic relevance of inactive PLTP. Futhermore we plan to define the interaction of PLTP with cellular ABCA1 and its role in reverse lipid transport. Research on lipid metabolism in the brain will explore the effect of PLTP on apolipoprotein expression and secretion in astrocytes and the potential role of PLTP in abeta formation and aggregation.

Amory, John, M.D.

Assistant Professor of Medicine, Div. General Internal Medicine, University of Washington

Endocrinology

(206) 616-1727
jamory@u.washington.edu

The Center for Research in Reproduction and Contraception is headed by Dr. William J. Bremner MD, PhD, the chairman of the Department of Medicine. Our group, which also includes: Dr. Alvin Matsumoto, Dr. Bradley Anawalt, Dr. John Amory and Dr. Stephanie Page conducts clinical research into male reproduction, including studies on: male contraceptive development, androgen replacement and testicular, pituitary and prostate physiology.

Arnold, Richard W., M.D.

Associate Clinical Professor of Medicine, University of Washington, School of Medicine, Faculty Big Sky College

Education

(206) 520-1552
rarnold@uwpn.org

I am interested in issues related to physician /patient communication the skills required and how to teach those to medical students and medical residents.  Included in this would be special situations such as cross cultural communication, dealing with difficult patients, delivering bad news etc.

Baernstein, Amy, M.D.
Assist. Professor of Medicine, UW School of Medicine, Attending Physician, Harborview Medical Ctr, Emergency Trauma Center

Education

(206) 731-3263
abaer@u.washington.edu

I am involved in research regarding medical student education in the areas of communication and professionalism.

Becker, Pamela S., M.D., Ph.D.
Associate Professor, Department of Medicine, Division of Hematology

(206) 616-1589
pbecker@u.washington.edu

My laboratory research is in the field of acute myelogenous leukemia and hematopoietic stem cell gene therapy.  I have translational research projects in this area, with both basic laboratory aspects and clinical trials.

Blau, C. Anthony "Tony," M.D.

Associate Professor, Medicine, Division of Hematology

(206) 685-6873
tblau@u.washington.edu

My research interests are in gene and cell therapy.  In particular, we are interested in addressing what we feel is the single biggest obstacle to the future development of cell therapy, namely, the inability to control what happens to a cell, after it has been transplanted.   Our group is developing methods to control the fate of transplanted cells by genetic manipulation so that they can be controlled using biological or pharmaceutical drugs that can be administered in vivo.

Boeckh, Michael J.J., M.D.

Associate Member, FHCRC
Assistant Professor, UW Medicine/Allergy & Infectious Diseases

(206) 667-6702 or 667-4898
mboeckh@fhcrc.org

Studies in the laboratory are focused on translational aspects of cytomegalovirus and respiratory virus infections in immunocomprormised individuals. (1) CMV. CMV projects include studies of the mechanisms of transmission of CMV via stem cells, blood and solid organs products. These studies aim at molecular detection of CMV in these organs with the ultimate goal to identity transmitter before transplantation. Another focus in the lab is studies of CMV immune reconstitution. We examine immunereconstitution patterns after non-myeloablative transplantation from unrelated donors and in recipients of long-term suppressive valganciclovir. In HIV-infected individuals studies are ongoing to evaluate the interaction of CMV, HSV and HIV in the female genital tract. A prospective study is ongoing to evaluate this interaction using quantitative virology and several pathogenesis questions are being addressed, including the impact of multiple strain infection with CMV on HIV genital load and the immunologic control of CMV in the genital tract. Clinical CMV studies are directed at the evaluation of alternative antiviral strategies for early and late CMV disease as well as indirect effects of CMV. (2) Respiratory Virus Infections. Another important focus is the study of respiratory viruses in HCT recipients. In a prospective longitudinal study, we examine the role of respiratory viruses in the development of late airflow obstruction. Studies are also underway to examine the underlying mechanisms by which these viruses cause airflow obstruction. Additional studies are underway to characterize the cellular and humoral immune response to RSV and human metapneumovirus in healthy subjects and HCT recipients.

Bomsztyk, Karol, M.D.
Professor of Medicine, Adjunct Professor of Pharmacology

Signal transduction

(206) 616-7949 or 543-1014
karolb@u.washington.edu

The broad objective of our research is to explore the molecular networks that exist between signal  transduction pathways and processes that compose inducible gene expression, such as chromatin remodeling, transcription, RNA processing, and translation.  We are particularly interested in the interactions between molecules that regulate gene expression and growth factor-responsive protein kinases. We use genetic, biochemical, and  computational strategies to define these fundamental processes across a spectrum of species from yeast to mammalian cells. It is anticipated that knowledge derived from studies on the interactions between inducible kinases and regulators of gene expression could be used to develop model systems to better understand diseases with the hallmark of abnormal cell growth and proliferation.

Bornstein, Paul, M.D.
Professor of Biochemistry and Medicine, Department of Biochemistry

(206) 543-1789
bornsten@u.washington.edu

The major interests of the laboratory include: 1) studies of the effects of matricellular proteins, primarily thrombospondins (TSPs) 1 and 2, on cell function and cell-matrix interactions; 2) studies of mice with a targeted deletion in the first intron of the Col1a1 gene that predisposes the mice to age-dependent aortic dissection and rupture; and 3) the function of the NH 2 -terminal propeptide of type I collagen in morphogenesis and development.

The following projects are under investigation :

The role of matrix metalloproteinases (MMPs) in the defects observed in TSP2-null mice, the mechanism of inhibition of angiogenesis by TSP2, studies of MMP2/TSP2 double-null mice, the use of local gene therapy to regulate expression of TSP2, MMP9, and MCP-in wound healing and in the foreign body reaction, the role of MMP2 in modulating tissue transglutaminase activity and the cross- linking of matrix proteins, including collagen, studies of the mechanisms involved in the reduced collagen synthesis observed in mice with a targeted mutation in intron 1 of the Col1a1 gene, studies of the interactions of the NH 2 -terminal propeptide of type I collagen with members of the BMP/TGF b family of proteins, and their functional consequences.

Boyko, Edward J., MD, MPH
Professor of Medicine, UW; Director, Seattle ERIC, VAPSHCS

Epidemiology, Endocrinology

Campus Box: 358280 (S-152E)
1660 S. Columbian Way
Seattle, WA 98108
Tel: 206-764-2830
Fax: 206-764-2563
eboyko@u.washington.edu

Epidemiology; Type 2 diabetes; Diabetic foot complications; Obesity; Metabolic syndrome. Epidemiological studies of factors that predict the development of hyperglycemia and weight gain.

Bremner, William J., MD, PhD
Robert G. Petersdorf Professor and Chair, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition

wbremner@u.washington.edu
Profile

Clinical studies of male reproductive endocrinology including the role of androgen replacement therapy and male contraceptive techniques.

Byers, Peter, M.D.
Professor, Pathology and Medicine

Genetics

(206) 543-4206
pbyers@u.washington.edu

My group is involved in the identification of genes and mutations in those genes that give rise to heritable disorders of connective tissue, in the phenotypes that arise from those mutations, and the way in which mutations are "translated" to phenotypes. Projects range from analysis of clinical information from individuals with known mutations in genes of type I or type III collagen, mutation analysis in a select group of individuals, characterizing the manner and order in which introns are removed in the presence of absence of mutations in these genes, identification of proteins in the cell that recognize abnormal collagen proteins, analysis of the risk of mosaicism for mutations in parents of first affected individuals in families, and many more. It would be a pleasure to be able to help provide some direction for a resident in Medicine and to see if this interaction would help guide them to Medical Genetics.

Centurion, Arturo , M.D.
Research Assistant Professor
Department of Medicine, Division of Infectious Diseases, University of Washington at Harborview Medical Center

(206) 341- 5364
acentur@u.washington.edu

Research in this laboratory focuses on Treponema pallidum, the etiologic agent of syphilis. I am interested in regulation of gene expression and the mechanisms of immune evasion and adaptation such as antigenic variation and phase variation. We have identified the first mechanism of antigenic variation in syphilis responsible for the generation of tprK diversity. We have also recently identified "G" homopolymeric repeats in the promoter regions in some members of the tpr gene family. It is likely that poly "G" tracts are involved in ON-OFF switch mechanisms of gene expression regulation.

Corey, Lawrence , M.D.
Virology Division, UW; FHCRC

Infectious diseases

(206) 667-6770
lcorey@u.washington.edu
COS Profile
Program in Infectious Diseases homepage

Research in Dr. Corey's laboratories deals with the pathogenesis, prevention and treatment of herpes virus and HIV infections. Dr. Corey is Head of the Program in Infectious Diseases at the Fred Hutchinson Cancer Research Center and as such, is interested in the treatment and prevention of infection in those undergoing HSCT. The research programs under Dr. Corey's direction involve both clinical and laboratory investigation, including development of molecular diagnostic methods to detect human viral infections, studies of the host response to HSV infections, the development of vaccines for HIV and HSV-2, studies of the virology and cell biology of human herpes virus type 8, and studies of the role herpesvirus infections play in transplantation biology. In addition, Dr. Corey is the PI of the NIAID supported HIV Vaccine Trials Network, the international clinical trials network established to evaluate and test candidate HIV vaccines.

Laboratory Studies in the Corey program include:

1. Studies to define T cell responses to HSV in both HIV, immunosuppressed and immunocompetent patients. This program includes studies to define the T cell responses to HSV-2, including defining epitopes for the CD8 response and use of in situ tetramer study of genital lesions. These studies are done in collaboration with Drs. Chris Posavad and David Koelle.

2. HIV Laboratory. This laboratory is interested in quantitative assays of HIV infection in tissues and in purified populations of cells and to define persistent/latent sites of HIV infection among those on therapy. Strong collaborations exist with the laboratories of Dr. Jim Mullins in the Department of Microbiology and Dr. Tuofu Zhu in the Department of Laboratory Medicine.

3. HSV-HIV Interactions. Epidemiologic and biologic studies show HSV influences HIV replication and vice versa. Studies to define in vivo expression of HIV-1 when HSV is present are also under investigation.

4. Studies to define the means of acquisition/transmission of HHV-8. These include molecular studies to define the growth and replication of HHV-8 in epithelial and endothelial cells, as well as epidemiological studies to define HHV-8 acquisition and transmission.

Crane, Paul K., M.D., MPH

Acting Instructor, Internal Medicine Harborview Hall

Health care delivery, Assessment

(206) 341-4451
pcrane@u.washington.edu

Medical psychometrics, measurement, dementia, cognition, aging, epidemiology, biostatistics. I have written a systematic review and received fellowship training in health services, so have a fairly broad toolkit to offer.

Curtis, J. Randall, M.D.
Associate Professor, Division of Pulmonary and Critical Care Harborview Medical Center

Health care delivery, End of life care

(206) 731-2106
jrc@u.washington.edu

Dr. Curtis' research program focuses on measuring and improving end-of-life care and palliative care. In particular, this program focuses on patients with chronic pulmonary disease such as COPD and also patients with critical illness.

Desnick, Laurel, MD
Attending physician, Internal Medicine, Women's Health Care Center, UWMC Roosevelt

Health care delivery, Education

ldesnick@u.washington.edu

Project: Update and expand Internal Medicine Residency website for international rotations and healthcare for the underserved.

1. Research new sites for both international rotations and underserved sites in the U. S.
2. Research sites for public health research and fellowship opportunities for international and community-based medicine for underserved populations.
3. Add resources for language studies, cultural clues, etc. for health care workers.

Project in the Women's Health Care Center at UWMC Roosevelt:

Develop evidence-based guidelines for one or more of the problems, including diagnosis and treatment protocols. Special attention to aspects of problems particular to female patients.

Deyo, Richard A., M.D., MPH Professor of Medicine and Health Services

Health care delivery (assessment)

(206) 616-0906 or (206) 543-9289
deyo@u.washington.edu

NIAMS Multidisciplinary Clinical Research Center: This NIAMS Multidisciplinary Clinical Research Center is focused on spine and upper extremity disorders because they are both common and disabling in the working age population. The center's projects focus in particular on back-pain, neck pain, and carpal tunnel syndrome, all of which are conditions that result in substantial work loss and high costs in the workplace. Furthermore, all are associated with controversy regarding diagnostic criteria and optimal treatment. The four major projects are a randomized trial of surgical vs. non-surgical treatment of mild carpal tunnel syndrome; a prospective cohort study of patients with "discogenic" low back pain (undergoing surgical or non-surgical treatment); an analysis of national databases to examine patterns of spine surgery; and a study that attempts to demonstrate the feasibility of digitally combining CT and MRI images of the cervical spine. The center is addressing optimal diagnostic approaches and evaluating treatment options for these conditions. In addition, it is examining characteristics of patients and medical care that predict getting poor outcomes. These predictors include both physical and psychosocial factors.

Disis, Mary L. "Nora," M.D. Associate Professor of Medicine, UW; Associate Member, FHCRC

Oncology

Tel: (206) 598-4702 or (206) 616-1823
ndisis@u.washington.edu
Tumor Vaccine Group

Her research centers on the identification and evaluation of potential immunogenic proteins specific for solid tumors to be used in the treatment and prevention (through immunotherapy) of human malignancies. Major projects include: (1) development of tumor antigen specific vaccines for the prs to assess the effect of the generation of an immune response to immunogenic cancer proteins and to evaluate different vaccine and adoptive immunotherapy strategies, (4) phase I/II clinical trials of peptide and DNA vaccines targeting specific cancer antigens, (5) phase I/II clinical trials of infusion of antigen competent T cells in patients with advanced stage solid tumors, (6) antigen discovery in solid tumors using molecular immunology and protein based techniques, and (7) development of in vivo imaging techniques for tracking tumor specific T cells and assessing the response to tumor specific immunotherapy.

Dominitz, Jason , M.D., MHS
Associate Professor of Medicine, Division of Gastroenterology, UW; Director, Northwest Hepatitis C Resource Center, VA Puget Sound Health Care System

Epidemiology, Gastroenterology

(206) 764-2285
Jason.Dominitz@med.va.gov

Dr. Dominitz is a gastrenterologist on the faculty of the University of Washington School of Medicine and directs the Northwest Hepatitis C Resource Center. He also works as a core investigator at the Seattle Epidemiologic Research and Information Center as well as the Northwest Health Services Research and Development Center of Excellence. In addition, he is an affiliate investigator at the Fred Hutchinson Cancer Research Center. His current research interests include the epidemiology of gastrointestinal malignancies (particularly colorectal cancer) and hepatitis C, and health services and pharmacoepidemiologic research using administrative databases.

Eisenberg, Mickey S., M.D. Professor, Division of Emergency Medicine, Box 356123, Medical Program Director, King County Emergency Medical Services, UWMC

Emergency Medicine

(206) 296-4553 or 598-4224
ging7@u.washington.edu

Our research area includes sudden cardiac arrest, acute myocardial infarction, defibrillation, and prehospital emergency medical services. We have worked with residents on research projects in the past and would love to continue doing this.

Elkon, Keith B., M.D.
Head, Dept of Medicine, Division of Rheumatology

(206) 543-3414
elkon@u.washington.edu

Dr. Elkon's research objective is to better define the molecular and genetic basis for autoimmune diseases such as lupus and arthritis. . SLE, also called lupus, is an autoimmune disease characterized by autoantibodies directed against nuclear antigens (ANA). The reasons why nuclear antigens, and DNA in particular, become targets for autoimmunity are unknown. Much attention has recently focused on defects in the process of apoptosis (programmed cell death)and the handling of cellular debris. Of interest, knockout of genes involved in apoptosis or the clearance of apoptotic debris, develop a lupus-like disease. We are testing the hypothesis that modification of nuclear antigens such as DNA in apoptotic cells lead to activation of the innate immune system by activating toll like receptors (TLR) in macrphages or dendritic cells. The TLR family of pattern-recognition receptors has emerged as a pivotal family of proteins that initiate inflammatory responses, and TLR9 has a particularly relevant role in the response to DNA.

Elmore, Joann G., M.D., MPH Associate Professor, Medicine; Adjunct Professor, Epidemiology; Section Head, General Internal Medicine, Harborview Medical Center; Associate Director, Robert Wood Johnson Clinical Scholars Program

Health care delivery (assessment)

(206) 731-3680
jelmore@u.washington.edu

I do research on cancer screening, especially breast cancer. Other interests include diagnostic evaluation and testing, and observer variability.

Fredricks, David N., M.D.
Assistant Professor, Dept of Medicine, Division of Allergy and Infectious Diseases, UW; Assistant Member, Program in Infectious Diseases, FHCRC

(206) 667-1935
dfredric@fhcrc.org

Molecular identification of bacteria associated with bacterial vaginosis.  This would be a hands-on laboratory based research project learning skills in molecular biology and applying them to study the microbiology of bacterial vaginosis. It would be a good project for a resident interested in infectious diseases.

Gopal, Ajay K., M.D.
Assistant Professor, Division of Medical Oncology, UW; Assistant. Member, FHCRC, SCCA

Oncology

(206) 288-2037
agopal@u.washington.edu
COS Profile

My research interests include immunotherapeutic strategies to treat lymphomas. Most projects would involve clinical research, but a lab-based project could likely be arranged. I would also be open to mentoring for projects that are more general in nature such as supportive care issues, ethics, doctor-patient communication, etc as it relates to oncology though these would require more advanced planning.

Hallstrand, Teal S., M.D., MPH
Assistant Professor, Medicine
Division of Pulmonary & Critical Care

(206)-221-6506
tealh@u.washington.edu

The overall goal of our laboratory is to understand how the underlying features of airway inflammation and remodeling lead to the clinical manifestations of asthma. Much of our recent work has been on the role of airway inflammation and epithelial remodeling in exercise-induced bronchoconstriction, a distinctive, but common manifestation of asthma. We use minimally invasive techniques to sample airway cells and airway lining fluid to detect changes in airway inflammatory cells, levels of inflammatory mediators, and markers of oxidative stress. We have also developed laboratory techniques to identify alterations in airway gene expression. Although the focus of our laboratory is on asthma, the techniques we use such as induced sputum and exhaled breath condensate analysis are widely applicable to other airway diseases such as COPD, CF, and bronchiectasis.

Harrington, Robert D., M.D. Associate Professor of Medicine, UW School of Medicine, Harborview Medical Center

Epidemiology, Infectious diseases

(206) 731-5145
rdh@u.washington.edu

I do mostly clinical care. I could be a mentor to resident who is interested in clinical infectious diseases and HIV research. Projects would likely be descriptive clinical studies based on chart reviews. These types of projects are less glamorous than others but are more feasible for residents that have limited time.

Hazzard, William R., M.D.
Director, Geriatrics and Extended Care, VA Puget Sound Health Care System; Professor of Medicine, UW

Epidemiology, Geriatrics

(206)764-2723
william.hazzard@med.va.gov

I continue to be intrigued by the possible role of the regulation of lipoprotein metabolism (especially in the CNS) and the pathogenesis (and potential prevention) of Alzheimer's Disease.  Probing this issue by review of the extant literature and the thoughts of UW faculty in Metabolism and the Alzheimer's Disease Research Center under my mentorship with implications for GCRC-based studies of this issue could prove fruitful and stimulating for residents willing to cross traditional disciplinary lines to investigate this disease that so challenges internists, psychiatrists, neurologists, and geriatricians.

Heinecke, Jay W., M.D. Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition

(206) 543-3158 or 543-3470
heinecke@u.washington.edu

Research in our laboratory focuses on the role of oxidative reactions in the pathogenesis of atherosclerosis, cancer and other inflammatory diseases. Our efforts are directed towards identifying oxidation products generated by activated phagocyte, which have been implicated in the damage of cellular targets. We employ a variety of techniques which combine protein, lipid and nucleic acid chemistry with a wide range of analytical techniques including mass spectrometry, high-performance liquid chromatography and high resolution nuclear magnetic resonance spectroscopy. To establish the physiological importance of oxidative stress in human disease - including atherosclerosis, ischemia/reperfusion injury, and other inflammatory states - we utilize a variety of mass spectrometric techniques to detect oxidation products generated in vivo.

A second major focus of the laboratory is the use of animals with genetically engineered deficiencies in phagocyte oxidant generation and antioxidant defense mechanisms to understand the pathogenesis of vascular disease and cancer. Recent animal studies have identified novel antioxidants with potent inhibitory effects on physiologically relevant pathways for oxidative damage. We are using animal models of atherosclerosis and other disorders to understand the biochemical mechanisms underlying these cardioprotective and anti-inflammatory effects. The identification of specific pathways for oxidative damage in vivo should provide a critical first step in the design of antioxidant interventions designed to interrupt a wide variety of inflammatory diseases.

Horwitz, Marshall , M.D., Ph.D.
Associate Professor, Dept. of Medicine, Div. Medical Genetics

(206) 616-4566
horwitz@u.washington.edu

The goal of the laboratory is to elucidate the molecular mechanisms of leukemia, lymphoma, and bone marrow failure through the study of heritable disorders predisposing to such illnesses. To date we have identified genes responsible for human cyclic neutropenia (ELA2, encoding neutrophil elastase), canine cyclic neutropenia (AP3B1, encoding a subunit of the AP3 intracellular transporter), human severe congenital neutropenia (ELA2 and also the oncogenic transcription factor Gfi1) and have confirmed the identity of a gene responsible for familial platelet disorder with pre-disposition to leukemia (Runx-1, encoding the transcription factor AML1). We have mapped presumptive loci for familial acute myelogenous leukemia to chromosome 16q and for familial Hodgkin's disease to the pseudoautosomal regions of the sex chromosomes and a second, autosomal locus on chromosome 3p21, on the basis of a recurrent chromosome translocation.

Hough, Terri , M.D.
Department of Medicine, Division of Pulmonary & Critical Care Medicine, HMC

Epidemiology, Pulmonary

Tel: (206) 731-4523
cterrlee@u.washington.edu

Outcomes after Critical Illness with a focus on ARDS. My current investigations are studies of muscle weakness and injury in survivors of ARDS.

Jackson, J. Carey , M.D.
Associate Professor, Medicine, Division of General Internal Medicine, Medical Director, Refugee Clinic, HMC

Health care delivery, Assessment, Education

(206) 341-4430
jacksonc@u.washington.edu

My research focuses on health services design and evaluation for immigrant and refugee communities. We also address certain health disparities in these same communities: specifically tuberculosis, hepatitis B, cervical cancer, hepatoma. We do internet-based provider education for providers caring for these same populations. We also train interpreters and evaluate interpretation issues in clinical encounters such as end of life, or inclusion in clinical trials.

Josephson, Neil , M.D.
Assistant Professor, Division of Hematology, Puget Sound Blood Center

Tel: 206-398-5970
njoseph@u.washington.edu

My laboratory has 2 areas of active research: 1. The development of foamy virus vectors for hematopoietic stem cell gene therapy to treat inherited blood disorders.  We are currently focusing on the disease Congenital Amegakaryocytic Thrombocytopenia (CAMT).  2.  Antigen targeting to tolerogenic dendritic cells for the induction of tolerance to factor VIII in patients with hemophilia.

Kahn, Steven E., M.D., MB, ChB Department of Medicine, Endocrinology, Metabolism, and Nutrition, VAPSHCS

Endocrinology

(206) 764-2148
skahn@u.washington.edu

Dr. Kahn's and his group are interested in the pathogenesis of the insulin resistance and ß-cell dysfunction observed in subjects with type 2 diabetes and related disorders. Their studies involve quantification of these parameters and assessing their relationship to a number of phenotypic variables commonly observed with states such as the metabolic syndrome. Opportunities for residents interested in glucose metabolism and related diseases includes hands on work with human subjects and/or the opportunity to address questions related to these areas by analysis of databases developed by the group.

Kapur, Vishesh , M.D., MPH Assistant Professor, Dept. of Medicine, Division of Pulmonary and Critical Care Medicine

Epidemiology, Sleep disorders, Health care delivery, Assessment

(206) 731-5703
vkapur@u.washington.edu

Primary research interests are clinical epidemiology, healthcare utilization and outcomes research in sleep disorders. A co-investigator in The Sleep Heart Health Study, a multi-center study of cardiovascular outcomes in sleep apnea. Also involved in several studies of sleep disordered breathing that focus on topics such as spinal cord injury, cognitive function and treatment outcomes.

Kaufman, Joel, M.D., MPH
Associate Professor, Departments of Environmental & Occupational Health Sciences, Medicine; Director, Occupational and Environmental Medicine Program

Mechanism of disease, Epidemiology, Occupational Medicine

(206) 616-3501
joelk@washington.edu

My research is currently focused on exploring the relationship between environmental factors (especially fine particulate air pollution) and cardiovascular and respiratory disease.  There are two major groups of projects ongoing: (1)  Effects of diesel exhaust on endothelial function.  In a series of experiments involving human subjects and transgenic mice (not at the same time), we are investigating whether diluted diesel exhaust inhalation causes detectable changes in endothelial function, and whether these changes are mediated through oxidative stress.  Related studies are also planned in asthmatic subjects, to determine how diesel exhaust exacerbates asthma. (2)  Air pollutants, subclinical progression of atherosclerosis, and clinical cardiovascular events.  In a major multi-center epidemiological study, we are investigating whether exposure to fine particulate air pollution is associated with progression of atherosclerosis, as measured by coronary artery calcification (CT Scan) and carotid wall thickness (intimal media thickness by ultrasound).  This study is determining individual level exposure to air pollutants in 8700 participants in nine communities with varying air pollution exposures.

Knopp, Robert H., M.D.
Chief, Division of Metabolism, Endocrinology and Nutrition, HMC

Metabolism

(206) 744-9116
rhknopp@u.washington.edu

The overall goal of patient oriented research at the Northwest Lipid Research Clinic at Harborview is to develop improved dietary, supplement and drug mediated treatments of simple and combined hyperlipidemia.  A second goal is to develop treatment programs that will avoid common side effects that complicate hyperlipidemia management. Out-patient studies are curently underway to investigate the effects of dietary and drug interventions on lipoproteins and other CVD risk factors.  Currently under investigation is an assessment the effects of omega-3 fatty acid administration on brachial artery reactivity determined by ultasound.  Plasma lipoproteins, oxidant stress status and nitric oxide metabolites are being monitored in this double blind, placebo- controlled investigation.  Another area of proposed research is to compare the effects of different statins on symptomatic myalgias and quadriceps muscle histology in an effort to determine mechanisms and lipid lowering treatment protocols that minimize or avoid myalgia symptoms. A third study is examining the effect of atrovastatin alone or with a time-release form of niacin (Niaspan) on lipoproteins and inflammation in persons with below average levels of HDL cholesterol.

Koelle, David, M.D.
Associate Professor, Medicine, Allergy and Infectious Diseases Harborview Research and Training Building

Immunology

(206) 341-5207
viralimm@u.washington.edu
COS Profile
Lab homepage

Our lab is interested in the cellular immune response to viral infections of humans.  Most of the work is on the sexually transmitted infection, herpes simplex virus type 2 (HSV-2).  We use molecular libraries and other methods to identify the HSV-2 proteins and peptides recognized by classical virus-specific CD4 and CD8 T-cells.  Some of the newly discovered antigens are working their way towards immunotherapeutic or prophylactic vaccines, and we are starting animal models.  A signifcant effort is going towards understanding how T-cells home to the skin.  HSV-2 is typically limited to skin and precise trafficking mechanims guide memory T-cells to various tissues and organs.  We are examing HSV-2 sequences for evidence of immune escape: does the virus change to evade T-cells?  A second focus is the cellular immune response to vaccinia, the vaccine used to prevent smallpox.  We are funded to discover T-cell antigens in vaccinia.  A rotation in the lab would be appropriate for a resident who was not put off by "hard core" immunology and molecular biology.  The concepts of immunology are laterally transferable between infectious diseases, oncology, and autoimmunity (rheumatology, etc.).

Kowdley, Kris V., M.D., FACP
Professor of Medicine Gastroenterology/Hepatology

Epidemiology, Gastroenterology

(206) 598-2076
kkowdley@u.washington.edu

Our patient-oriented and translational research program is focused in three broad areas: Genotype/Phenotype Correlations in Hemochromatosis; Epidemiology, Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease; Epidemiology of Hepatitis B; and Cholesatic Liver disease. A number of research opportunities are available, ranging from retrospective chart review studies, prospective intervention studies and case-control studies. We have a number of sources of data, including a database of >400 well-characterized patients referred for iron overload, established registries in Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, hepatitis B and access to large databases of patients from previously completed NIH trials. In addition, there is the opportunity to learn lab techniques such as RT-PCR, Immunohistochemcial staining, methods for measuring insulin sensitivity, clinical trial design and database analysis from NHANES I and NHANES III datasets. Our research group can provide support to the resident starting in patient-oriented or translational research with research coordinator and statistical support, Access databases, IRB application and in the ethical conduct of research.

Laya, Mary B., M.D., MPH Associate Professor of Medicine, Women's Health Care Center

Epidemiology, Women's Health, Health Care Delivery, Assessment

206-598-4958
mlaya@u.washington.edu

Research opportunities with me in the Women's Health Care Center include clinical epidemiology, quality improvement focusing on implementation of screening guidelines, clinical correlates of patient satifaction and application of evidence-based practice guidelines in the outpatient setting. A variety of clinical and administrative data-bases are available for use in QI projects. Special areas of focus include epidemiology, diagnosis, treatment and monitoring of osteoporosis and breast cancer screening and clinical detection.

Liles, W. Conrad , M.D., Ph.D. Associate Professor of Medicine, Division of Infectious Diseases, Department of Medicine, Adjunct Associate Professor of Pathology

Immunology

(206) 598-0668
foghorn@u.washington.edu

My laboratory is involved in translational research in innate immunity. The overall mission of our research is to investigate clinical problems at the bench, in order to gain novel insights into disease pathogenesis and to develop potential new therapeutic approaches to important clinical problems. Areas of current research include: 1. The regulation of apoptosis in human phagocytes. 2. The role of apoptosis in the pathogenesis of acute inflammation and tissue injury with a current focus on acute lung injury/acute respiratory distress syndrome (ARDS). 3. Molecular defects in congenital disorders of neutrophil production and function. 4. Molecular and cellular pathogenesis of sepsis, the systemic inflammatory response syndrome, and multiple organ dysfunction syndrome. 5. Granulocyte transfusion therapy. 6. Use of cytokines to modulate host defense against opportunistic pathogens. 7. Role and regulation of apoptosis in vascular biology. 8. Role and regulation of human Toll-like receptors in innate immunity. 9. Mobilization of hematopoietic stem cells.

LoGerfo, James P., M.D., MPH
Professor of Medicine and Health Services
Director, UW Health Promotion Research Center

Geriatrics

(206) 731-8928
logerfo@u.washington.edu
Health Promotion Research Center website

The UW Health Promotion Research Center focuses on community based approaches to healthy aging. Our core project through 2009 is a two level intervention to increase levels of physical activity for older adults in SE Seattle. At the clinical-community support level we are working with community clinics and a senior center to conduct an RCT of physician referral to a community support system to help motivate uptake and maintenance of activity in older diabetics. At the community level we work with a number of community agencies and groups to create a more activity friendly social and physical environment. Other key projects include worksite based programs for employed older adult (50-65) population strategies; ongoing dissemination of previously developed effective strategies to promote healthy aging that were developed at HPRC; and working with several regional coalitions to promote physical activity in older adults. See website at http://depts.washington.edu/hprc/index.htm .

Malhotra, Uma, M.D.
Assistant Professor, Department of Medicine, Allergy and Infectious Diseases, UW, FHCRC

Infectious diseases, Health care delivery, Assessment

206-667-6738
umalhotr@fhcrc.org

My research studies encompass T cell immunity in HIV-1 infection. Specific areas of interest include: a)CD4 help in HIV-1 infection:The goal is to gain improved understanding of the barriers to the generation and maintenance of effective CD4 help in HIV-1 infection through studies in persons with acute infection and in those with long-term non-progressive disease; b)HIV-1diversity considerations in the evaluation of candidate vaccines: The goal is to develop standard testing approaches to evaluate candidate vaccine induced cellular responses and obtain objective data for the rapid advancement of the superior candidates through the development process; c) Virus diversity considerations in vaccine design: The goal is to identify highly immunogenic cross-reactive HIV-1 vaccine epitopes through the use of synthetic combinatorial peptide libraries with biometrical analysis; and d) AIDS International Training and Research Program (AITRP): The goal is to foster international collaborative multidisciplinary HIV prevention research between University of Washington scientists and colleagues at institutions in India through bilateral exchange of scholars for research training. Funding sources include the National Institutes of Health, HIV Vaccine Trials Network, Fogarty International Center, and the Puget Sound Partners for Global Health.

Marra, Christina M., M.D. Professor, Neurology, Adjunct Professor, Medicine (Infectious Diseases), HMC

Mechanism of disease, Neurology, Infectious diseases

(206) 341-5400 or 731-3251
cmarra@u.washington.edu

The focus of my research is on clinically relevant problems that relate to infections of the nervous system. My laboratory-based work concentrates on syphilis and neurosyphilis. We are particularly interested in identifying factors that predict the likelihood of neurosyphilis and that predict the response to treatment of neurosyphilis in HIV-infected and -uninfected individuals. I also participate in several clinical research projects that relate to the effects of HIV on the CNS.

Matsumoto, Alvin, M.D. Professor, Medicine, Div of Gerontology & Geriatric Medicine, UW School of Medicine; Clinical Director, Geriatric Research, Education and Clinical Center (GRECC); Director, Clinical Research Unit, VAPSHCS

Endocrinology

(206) 764-2308
Voicemail: (206) 764-2760
Alvin.Matsumoto@med.va.gov

Male reproductive endocrinology and aging, with emphasis on male hypogonadism, testosterone replacement therapy, androgen actions, spermatogenesis, and male contraception.

Matute-Bello, Gustavo, M.D. Assistant Professor of Medicine, Division of Pulmonary & Critical Care Med

(206) 277-4434
matuteb@u.washington.edu

My main interest is to understand the mechanisms leading to alveolar epithelial damage in acute lung injury, and the interactions of those mechanisms with lung host defenses. We have focused primarily on the role of apoptosis in the development of epithelial damage, with a particular emphasis on the Fas/FasL system. Our current hypothesis is that the Fas/FasL system plays multiple roles in the pathogenesis of acute lung injury, depending on the target cell: it contributes to destruction of the epithelium by promoting apoptosis of alveolar epithelial cells, it contributes to the fibrotic response by promoting fibroblast proliferation and collagen deposition, and it contributes to the inflammatory response by promoting cytokine release from alveolar macrophages. We are approaching this hypothesis by combining genomic and proteomic analyses, molecular biology techniques, cell biology, and experimental models of lung injury.

McClelland, R. Scott, M.D., MPH
Assistant Professor, Departments of Medicine and Epidemiology

Epidemiology, International health

UW Mombasa Field Site - Ganjoni
Fax: 254-41-474055
mcclell@africaonline.co.ke

My research involves studies of HIV-1 and STD epidemiology in Kenya. Specific areas of interest include antiretroviral therapy, HIV-1 susceptibility and infectivity, and HIV-1/nutrition.

McCormick, Wayne C., M.D. Associate Professor/Section Chief, Medicine, Division of Gerontology and Geriatric Medicine, Member, Long-Term Care Service

Health Care Delivery, Assessment

(206) 341-3900 or 994-2462
mccorm@u.washington.edu

The investigator intends to study advance directives in persons with dementia and the effect of directives on long term care utilization. The existence of a large prospective cohort of persons who have acquired dementia affords a unique opportunity to do so. The cohort is made up of older Caucasian Americans (N=2581) in the Seattle metro area; 800 have died, half of these had dementia.

Migeon, Mary, M.D.
Assistant Professor, Department of Medicine, Division of General Internal Medicine, UW School of Medicine

Health Care Delivery, Education

206-598-4538
mmigeon@u.washington.edu

My primary research interests are mental health in primary care, medical school teaching, and patient/physician communication.

Miller, Samuel I., M.D.
Professor, Department of Medicine, Division of Infectious Diseases

(206) 616-5110
millersi@u.washington.edu

The Miller laboratory is focused on defining the molecular basis of bacterial pathogenesis and interactions with eukaryotic cells.  This work involves the use of animal and tissue culture (mice, macrophages, epithelial cells) models of infection using Salmonella, Pseudomonas, and Yersinia.  The diseases of interest to us at the moment include Salmonellae-induced typhoid fever and gastroenteritis, the chronic Pseudomonas airway disease of cystic fibrosis patients, and Gram-negative organisms important to biodefense, including Francisella tularensis and the plague bacillis Yersinia pestis. The lab is organized into research groups focusing on the study of: (1) The effect of bacterial type III effector proteins on mammalian cells and the assembly and regulation of the type III secretion system of Salmonella typhimurium; 2) The environmental remodeling of the gram-negative bacterial surface that occurs when bacteria infect host tissues; and (3) The characterization of the phenotypic adaptation of Pseudomonas aeruginosa to the unique environmental niche of the CF airway.  Current projects within each group include the study of: (1) Salmonellae translocated effectors (which are delivered across the phagosome membrane and recruited to the actin cytoskeleton, nucleus, and phagosome) (2) Assembly of the type III secretion system inner membrane ring of the needle complex and structure-function analysis of the type III secretion chaperone InvB; (3) Remodeling of the surface of lipid A after bacterial infection of host tissues and analysis of the recognition of diverse lipid A by human Toll-like receptor 4; and (4) Proteomic analysis and transcriptional profiling of Pseudomonas aeruginosa adaptation during CF.

Montgomery, R. Bruce, M.D. Associate Professor, Department of Medicine, Division of Oncology

(206) 762-1010 ext.6878 or 598-0860
rbmontgo@u.washington.edu

Research in the laboratory focuses on immunotherapeutic targeting and modulation of drug resistance of prostate cancer. Current clinical research studies include a phase I study of a peptide vaccine to the mutant EGFRvIII in patients with prostate and ovarian cancer, being carried out in the GCRC under the auspices of SWOG. Other studies determine the effects of neoadjuvant estrogen on immunity to prostate cancer and estrogen augmentation of docetaxel chemotherapy in patients with advanced, hormone refractory prostate cancer.

Motulsky, Arno , M.D., Sc.D.
Professor Emeritus, Departments of Medicine, Division of Medical Genetics and Genome Sciences, UW School of Medicine

Mechanism of disease, Genetics

(206) 543-3593
agmot@u.washington.edu

Residents who are interested in working on a topic related to medical genetics, cardiology, oncology, and hematology will be particularly welcome, but I would consider residents in any field.

Mullins, James I., M.D.
Professor, Microbiology, Professor/ Adjunct Professor, Medicine/ Laboratory Medicine

Infectious diseases

(206) 732-6163
jmullins@u.washington.edu

I would be interested in mentoring 1 resident interested in basic research on HIV. The laboratory studies basic virology as well as HIV/host interactions.

Pagel, John, M., M.D., Ph.D.
Associate in Clinical Research, Transplant Clinic, SCCA

Hematology

(206) 667-1868
jpagel@fhcrc.org

The focus of our research is to investigate new and exciting therapeutic modalities for lymphoma and leukemia patients using immunotherapy approaches. On-going clinical trials have translated novel antibody based approaches to the care of patients undergoing stem cell transplantation. The overall objective in the laboratory is to translate our immunotherapy approaches to improve the efficacy and decrease the toxicity of therapy for patients with lymphomas and leukemias. In particular, we are attempting to improve on methodes of delivering radiation to malignant cells using radiolabeled monoclonal antibodies. The initial laboratory studies suggest that we can improve our approach to markedly enhance the efficacy and diminish toxicities compared with standard radioimmunotherapy. We plan to incorporate these new strategies into our ongoing program for patients with non-Hodgkin's lymphomas and leukemias. Success in achieving this objective should simultaneously permit higher cure rates and less toxicity than is currently attainable with conventional therapy.

Park, David R., M.D.
Assistant Professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine

(206) 731-3356 or 341-4122
drp@u.washington.edu

Clinical projects in Pulmonary and Critical Care Medicine, including transmissioin of infection in patients released from respiratory isolation.

Payne, Thomas, M.D.
Clinical Associate Professor, Medicine/General Internal Medicine, ITS

Health care delivery, assessment

(206) 616-8435 or 986-6628 tpayne@u.washington.edu

I am interested in large scale clinical computing systems--especially electronic health records--and how to measure their utility and effect on clinician workflow. Examples of current projects are studying how physicians document care and override rates of CPOE (computerized practitioner order entry) alerts. I'm also interested in how electronic clinical notes are created, reviewed, edited, and authenticated within electronic health record systems.

Raskind, Wendy, M.D.
Professor of Medicine, Division of Medical Genetics, Professor of Psychiatry and Behavioral Sciences (Joint), Adjunct Professor of Genome Sciences, Department of Medicine

Mechanism of disease, Genetics

(206) 543-3177
wendyrun@u.washington.edu

My research focus is the molecular genetics of neurobehavioral disorders. We have mapped the loci for several Mendelian neurodegenerative disorders and are studying the complex inheritance of dyslexia.  We recently identified the gene for spinocerebellar ataxia type 14 (SCA14) and are developing a mouse model for this disorder.

Raugi, Gregory J., M.D., Ph.D.
Associate Professor of Medicine Division of Dermatology, VAPSHCS

Dermatology

(206) 764-2305 skin@u.washington.edu

Diabetic foot ulcers are a major health care problem among veterans. Veterans receiving care at the VA had 90,000 foot ulcers, 12,000 hospitalizations, and 3400 lower limb amputations during a recent year. Our research is focused on developing and testing interventions to decrease the disability associated with foot ulcers, save limbs, and prevent re-ulceration.

Rea, Thomas D., M.D.
Acting Assistant Professor, Medicine/General Internal Medicine

Emergency Medicine

(206) 521-1750
rea123@u.washington.edu

Projects would likely involve emergency medicine and focus on cardiac arrest in the out-of-hospital setting. Any mentee would likely work with both myself and Professor of Medicine Mickey Eisenberg. The work would be performed in conjunction with the Division of Emergency Medical Services - Public Health - Seattle and King County.

Reed, May J., M.D.
Associate Professor of Medicine, Division of Gerontology and Geriatric Medicine

Geriatrics

(206) 341-5331 or 540-7153
mjr@u.washington.edu

The Reed laboratory examines mechanisms of impaired angiogenesis in aging. The laboratory uses in vitro models (endothelial cells and microvessels from young and aged donors) and in vivo models (implants in young and aged mice) to analyze the angiogenic response in the basal state and in the presence of modulators such as VEGF and nitric oxide. Methods include histologic examination and basic techniques in protein chemistry and molecular biology.

Rho, Robert W., M.D.
Assistant Professor, Department of Medicine, Division of Cardiology

(206) 685-4176
rrho@u.washington.edu

My research interests are in Biventricular pacing for congestive heart failure and in mapping and radiofrequency ablation of atrial and ventricular tachyarrhythmias. 

Richard, Robert , M.D., Ph.D. Assistant Professor, Division of Hematology, Department of Medicine, UW School of Medicine

(206) 616-9939
rrichard@u.washington.edu

I am interested in translating improvements in gene transfer technology into therapies for both acquired and inherited blood disorders. In particular retrovirus-based vectors can now target the hematopoietic stem cell at a high efficiency allowing the possibility of treating a wide variety of blood disorders. Combining these technological improvements in gene transfer with improvements in stem cell engraftment will result in new gene and cell therapy clinical trials. We are targeting two diseases: 1) Advanced HIV infection and 2) Sickle cell disease. We are addressing practical barriers to eventual gene therapy trials including the collection of stem cells and the development of new, alternative vector systems.

Salazar, Lupe G., M.D.
Acting Instructor, Hematology

Oncology

(206) 616-8503
lsalazar@u.washington.edu

My current research focuses on the development of novel Phase I studies for immunotherapy, such as tumor vaccines for the treatment and/or prevention of solid tumors, as well as clinical trials evaluating molecularly-based methods of enhancing tumor-specific immunity in cancer patients. A particular interest is in the assessment of the development of immunologic memory as the endpoint of a successful cancer vaccine.

Schnapp, Lynn M., M.D.
Associate Professor, Pulmonary and Critical Care Medicine, UW, HMC

Mechanism of disease, Pulmonary

(206) 341-5389,
lschnapp@u.washington.edu

We are interested in identifiying new pathways and proteins that are involved in the development of acute lung injury in critically ill patients. We are using proteomics to analyze bronchoalveolar lavage sdamples from patients, then verifying presence of proteins by conventional methods. We will then determine functional significance.

Scott, Bart L., M.D.
Research Associate, UWMC, FHCRC

Hematology

Tel: (206) 667-1990 ,
bscott@fhcrc.org

My research interests focuses on clinical trial development for Myelodysplastic Syndromes (MDS).  To date we have 4 active protocols investigating new treatment modalities for MDS.  Our clinical trials deal with both transplant and non-transplant studies.  We currently have in development a randomized trial comparing nonmyeloablative transplantation to myeloablative transplantation in patients with MDS, and a clinical trial combining azacytidine with etanercept as a non-transplant treatment for patients with MDS.  We see over 150 new diagnosis of MDS/year with 2-3 new cases every week.

Simkin, Peter A., M.D.
Professor of Medicine, Division of Rheumatology

Mechanism of disease, Rheumatology

(206) 543-3414
psimkin@u.washington.edu

My primary interests are in the structure and function of normal joints and the clinical physiology of rheumatic diseases.  Specific themes include  subchondral trabeculae as hydraulic springs (and perhaps the major locatiion of "the spring in your step"), the tidemark of cartilage as a depot for apoptotic debris (and potential antigenic driver for rheumatoid arthritis), the role of the liver as an endocrine governor of uric acid reabsorption by the kidney, etc. I would be delighted to discuss these ideas (and more) with any resident who is interested.

Slichter, Sherrill J., M.D. Executive Vice President of Research, Puget Sound Blood Center

Hematology

(206) 292-6541
sjslichter@psbc.org

My research focuses on the pathophysiologic effects of platelet transfusion therapy proceeding from the appropriate collection and storage of platelets for transfusion, to planning effective platelet transfusion therapy, and, finally, to evaluating methods of preventing platelet alloimmunization.

Platelet Storage Studies: Under a grant received from the NIH, we have been evaluating methods of extending platelet storage. Specifically, we have documented that we can maintain platelet viability at levels at least half of normal values for eight days. However, if platelets are stored in a physiologic solution rather than residual plasma, platelet storage can be extended to 13 days. These studies have been done using radiolabeled platelet recovery and survival measurements of autologous stored platelets in normal volunteers. Our next studies will be to transfuse extended stored platelets into thrombocytopenic patients to document the recovery, survival and function of these platelets.

Effective Platelet Transfusion Therapy: We have recently been selected as one of 17 trial sites across the U.S. that will be participating in a NHLBI sponsored Transfusion Medicine/ Hemostasis Clinical Trials Network. The platelet dose trial that we had submitted as part of our proposal has been selected as the first study that will be initiated by this new network. This will give our community an opportunity to participate in this trial which will likely change transfusion practice.

Prevention of Platelet Alloimmunization: We have utilized a dog platelet transfusion model for the last several years to evaluate questions related to platelet alloimmunization. Our current studies are focused on identifying the alloimmunizing as well as the tolerizing white cells and, in addition, to determine the role of DLA (dog lymphocyte antigen) compatibility between donor and recipient in tolerance induction.

Smith, C. Scott, M.D.
Associate Professor, General Internal Medicine and Medical Education and Biomedical Informatics

Health care delivery, Education

(208) 422-1325
Scott.Smith2@med.va.gov

My team does research on improvements in outpatient teaching clinics. We use mixed qualitative quantitative methods including observation, focus groups, interviews, and Cultural Consensus Analysis (CCA--a technique used by anthropologists to identify groups with shared values). The information from CCA is used to identify and inform a specific process of improvement. We are currently doing multi-site trials of these techniques and instruments created during our earlier studies.

Stempien-Otero, April, M.D. Assistant Professor of Medicine, Division of Cardiology

(206) 598-6190
april@u.washington.edu

I have a basic laboratory studying cardiac fibrosis using transgenic mice.

Stewart, Grace C. John, M.D., Ph.D., MPH
Associate Professor, Medicine, Allergy and Infectious Diseases IARTP, Adjunct Associate Professor, Department of Epidemiology, International AIDS Research and Training Program HMC

Epidemiology, Infectious disease

(206) 543-4278 or 543-3138
gjohn@africaonline.co.ke

Our research is based in Nairobi, Kenya and involves HIV-1 studies.

Strote, Jared, M.D., MS
Clinical Instructor, UWMC Division of Emergency Medicine

Health care delivery, Assessment

206 598-0103
strote@earthlink.net

My interests and projects are: Pre-hospital care, Resuscitation, Clinical efficiency, Violence prevention, and Ethics

Swenson, Eric, M.D.
Professor of Medicine, Physiology and Biophysics, Pulmonary and Critical Care Medicine Division , VAPSHCS

Mechanism of disease, Pulmonary

(206) 764 2504
Erik.Swenson@med.va.gov

1. Adaptation and maladaptation to acute and chronic hypoxia studies include field and lab human investigations, live animal and isolated organ studies with particular emphasis on lung-heart-brain-kidney function and interactions and illness of high altitude such as acute mountain sickness and high altitude pulmonary edema; 2. Gas exchange and pulmonary vascular regulation with emphasis on hypoxic and hypercapnic responses and the role of nitric oxide in blood gas transport and oxygen delivery; 3. Erythropoietin, nitrite and other cytoprotective agents in lung ischemia reperfusion injury and emphysema; 4. Therapeutic hypercapnia in acute lung injury; 5. Gas exchange, acid-base balance, salt/water transport and vascular regulation in fish.

Wipf, Joyce E., M.D.
Professor, Dept. of Medicine, Div. of General Internal Medicine, Associate Director, Residency Training, VAPSHCS

Health care delivery, Education

(206) 762-1010 ext. 1650 or (206) 543-4205
jwipf@u.washington.edu

My research interest is relative to resident medical education topics. I have worked with residents on studies of burnout, work-hour limitations and impact on training, and volunteer activities.

Wolden-Hanson, Tami, Ph.D.
Department of Medicine, Division of Gerontology and Geriatrics, VAPSHCS

Geriatrics, Metabolism

(206) 768-5394
twh@u.washington.edu

Aging in humans and other animals is associated with a loss of the ability to maintain homeostasis in response to physiologic and environmental disturbances. One of the systems that is particularly affected with aging is that which regulates food intake and energy balance, leading to a decreased ability to maintain body weight and lean body mass in response to illness or disease. The reasons for this loss of regulation of energy balance are multi-factorial. However, one of the key factors appears to be a loss of appetite, termed the anorexia of aging. My work focuses on the neuroendocrine control of energy balance in aging rats. I use the Brown Norway rat model of successful aging to explore the interactions between the endocrine system and the areas of the brain that regulate energy homeostasis, with the aim of increasing food intake and preservation of body weight.

Wu, Daniel Y., M.D.
Assistant Professor, Department of Medicine, Division of Oncology, VAPSHCS

Mechanism disease, Oncology

(206) 764-2709 or 764-2278
danielw@u.washington.edu

The telomere-independent accelerated cellular senescence (ACS) has been described for hematopoetic and somatic cancer cells treated with chemotherapeutic drugs, radiation, oxidative and differentiating agents. In response to these agents, cells arrest irreversibly in cell cycle and exhibit characteristics senescence marker and morphology. Recently the work from my laboratory has established ACS as a physiological response to chemotherapy in human lung cancer and provided evidence of its presence in hypoproliferative myelodysplastic syndrome (MDS). Based on the predictable recurrence/progression of these diseases, we proposed that cancer cells arrested as result of ACS must be able to bypass the senescence program to regain proliferation. We have therefore established a model for ACS and escape using NCI-H1299 lung cell carcinoma cells treated with camptothecin. We found that H1299 cells arrested in cell cycle at G2 following chemotherapy can bypass ACS through the over-expression of cyclin dependent kinase Cdc2/Cdk1, such that the selective inhibition of Cdc2/Cdk1 in these senescence escape cells results in their rapid re-arrest and death. Given the importance of ACS in carcinogenesis and anti-cancer therapy, work is underway in my laboratory to examine essential elements that establish ACS and escape, as well as define its clinical importance. Specifically, we propose to delineate the requirements for "irreversibility" in ACS involving transcriptional, DNA methylation and protein mechanisms that establish sustained G2 checkpoint activation as well as examine the contribution of cyclin B1 and survivin. Clinical pathologic studies are also underway to examine markers of ACS and escape in clinical lung cancer and MDS. The long-term goal of this research is to identify in vivo mechanisms of ACS and escape so that novel strategies of anti-cancer therapy for MDS and solid tumors.

Yee, Cassian, M.D.
Associate Professor, Division of Oncology, UW; Associate Member, Program in Immunology, FHCRC

(206) 667-6287
cyee@fhcrc.org

Immunology, Melanoma, Ovarian Cancer, Tetramers, ImmuneMonitoring, CytokineImmunomodulation, and Antigen Discovery

Yu, Evan, M.D.
Assistant Professor, Dept of Medicine, Div of Oncology, UW, FHCRC

206-288-6292
evanyu@u.washington.edu

My goal is to perform translational research with bladder and prostate cancer. I am beginning to plan a bladder cancer urine, plasma, and tissue bank, and by next summer, I should hopefully be able to welcome and nurture an inquisitive resident who is interested in both clinical and basic research in oncology.